Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935664 | 0.84 | GAA (0.46) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL30935742 | 0.81 | TGFBR1 (0.55) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL312448 | 0.79 | PIK3CD (0.55) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1649636 | 0.78 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL14108205 | 0.78 | KDM4E (0.69) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL14738511 | 0.76 | TGFBR1 (0.50) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL312359 | 0.76 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL23728644 | 0.75 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL16691118 | 0.75 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL9941410 | 0.75 | TGFBR1 (0.61) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |