Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038928 | 0.84 | HTR2A (0.44) | HTR2AHTR2CHTR2BTBXAS1MAPT | |
| SCHEMBL4149577 | 0.81 | TSHR (0.41) | HTR2AHTR2CHTR2BTBXAS1HSD11B1 | |
| SCHEMBL3955274 | 0.81 | HTR2A (0.38) | HTR2AHTR2CHTR2BTBXAS1HSD11B1 | |
| SCHEMBL1082963 | 0.80 | MAPK1 (0.37) | MAPT | |
| SCHEMBL24656220 | 0.80 | TSHR (0.44) | HTR2AHTR2CHTR2BTBXAS1HSD11B1 | |
| SCHEMBL24656071 | 0.80 | TSHR (0.44) | HTR2AHTR2CHTR2BTBXAS1HSD11B1 | |
| SCHEMBL23435085 | 0.78 | CD38 (0.52) | CD38NAMPTWNT1DYRK1AHSD11B1 | |
| SCHEMBL14875386 | 0.77 | TBXAS1 (0.43) | CD38NAMPTTBXAS1 | |
| SCHEMBL7883953 | 0.75 | MAPK1 (0.31) | HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL28194248 | 0.74 | FAAH (0.39) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |