Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935664 | 0.82 | GAA (0.46) | CHEK2KDM4EALDH1A1GAANPC1 | |
| SCHEMBL14739009 | 0.77 | KDR (0.38) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL2052844 | 0.75 | KDM4E (0.43) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL9941639 | 0.73 | ALDH1A1 (0.44) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL9753645 | 0.73 | NPC1 (0.47) | KDM4AKDM4BKDM5CKDM5BKDR | |
| SCHEMBL14740159 | 0.72 | KDM4E (0.66) | KDM4EALDH1A1GAAPKMNPC1 | |
| SCHEMBL2051117 | 0.72 | KDM4E (0.43) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL14756581 | 0.72 | KDM4E (0.43) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL16370092 | 0.72 | NPC1 (0.52) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL14744038 | 0.72 | FLT3 (0.59) | FLT3NEK2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |