Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28482288 | 0.82 | RNASEH1 (0.68) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL1893620 | 0.81 | RNASEH1 (0.66) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL2230351 | 0.75 | HDAC6 (0.62) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL3950590 | 0.75 | RNASEH1 (1.00) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL4654055 | 0.72 | HDAC6 (0.67) | MAPTSMN1; SMN2HDAC6HDAC1HDAC4 | |
| SCHEMBL28513667 | 0.72 | RNASEH1 (0.55) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL31110177 | 0.72 | MAPT (1.00) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL11454295 | 0.71 | CYP1A2 (0.68) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 | |
| SCHEMBL3094688 | 0.69 | HDAC6 (1.00) | NPC1RAB9AHDAC6HDAC1HDAC4 | |
| SCHEMBL8825124 | 0.69 | MAPT (0.51) | RNASEH1MAPTSMN1; SMN2TP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799825-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-09-21 | — | — | US | disclosed |
| US-20090076101-A1 | Thiophene and Thiazole Substituted Trifluoroethanone Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076101-A1 | Thiophene and Thiazole Substituted Trifluoroethanone Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC4, HDAC7 | RNASEH1 725/4885MAPT 51/4885SMN1; SMN2 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.