Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27216867 | 1.00 | MAOB (0.40) | MAOBTGFBR1TRPA1GRM4IDO1 | |
| SCHEMBL27216850 | 0.89 | TGFBR1 (0.38) | TGFBR1GRM4IDO1KDM4EGAA | |
| SCHEMBL30936711 | 0.89 | TGFBR1 (0.38) | TGFBR1GRM4IDO1KDM4EGAA | |
| SCHEMBL30936735 | 0.89 | MAOB (0.43) | MAOBTGFBR1GRM4IDO1RAPGEF4 | |
| SCHEMBL27216835 | 0.89 | MAOB (0.43) | MAOBTGFBR1GRM4IDO1RAPGEF4 | |
| SCHEMBL30936717 | 0.86 | CDC7 (0.43) | CDC7MKNK1MEN1KMT2A | |
| SCHEMBL27216839 | 0.86 | CDC7 (0.43) | CDC7MKNK1MEN1KMT2A | |
| SCHEMBL23887998 | 0.86 | IDO1 (0.43) | TGFBR1GRM4IDO1MKNK1 | |
| SCHEMBL30176991 | 0.86 | IDO1 (0.43) | TGFBR1GRM4IDO1MKNK1 | |
| SCHEMBL30936738 | 0.83 | MAPK1 (0.47) | TGFBR1GRM4MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158404-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED | 2024-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240158404-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | SERPINA2, SERPINA3, SERPINB1 | MAOB 2003/4885TGFBR1 1116/4885TRPA1 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.