SCHEMBL30936784

SCHEMBL30936784

CCc1cc(Nc2ncc(Cl)c(Nc3ccc(OC)cc3NS(C)(=O)=O)n2)c(OC)cc1N1CCC(N2CCN(CCC(=O)O)CC2)CC1

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 18/20 0.62
▸ ALK Q9UM73 2/20 0.51
▸ PTK2 Q05397 1/20 0.51
▸ INSR P06213 1/20 0.50
▸ IGF1R P08069 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26906593 0.89 EGFR (0.69) EGFRALKINSRIGF1R
SCHEMBL30936763 0.88 EGFR (0.69) EGFR
SCHEMBL27076077 0.88 EGFR (0.60) EGFRALKINSRIGF1R
SCHEMBL30936805 0.88 EGFR (0.72) EGFRALKINSRIGF1R
SCHEMBL30937107 0.85 EGFR (0.67) EGFRALK
SCHEMBL30936957 0.84 EGFR (0.67) EGFRALK
SCHEMBL30936192 0.84 EGFR (0.52) EGFRALKPTK2
SCHEMBL30936935 0.83 EGFR (0.54) EGFRALKPTK2
SCHEMBL27075968 0.83 EGFR (0.70) EGFRALKPTK2INSRIGF1R
SCHEMBL26906822 0.82 EGFR (0.72) EGFRALKPTK2INSRIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024072178-A1 COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF (주)사이러스테라퓨틱스 2024-04-04 — — WO disclosed
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