SCHEMBL30936888

SCHEMBL30936888

CCOc1cccc(Nc2nc(Nc3cc(CC)c(N4CCC(N5CCNCC5)CC4)cc3OC)ncc2Cl)c1NS(C)(=O)=O

nearest known ligand 0.65

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 18/20 0.65
▸ ALK Q9UM73 2/20 0.52
▸ INSR P06213 1/20 0.51
▸ IGF1R P08069 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30936898 0.97 EGFR (0.67) EGFRALKINSRIGF1R
SCHEMBL30937137 0.94 EGFR (0.63) EGFRALKINSRIGF1R
SCHEMBL30936756 0.92 EGFR (0.67) EGFRALK
SCHEMBL27076040 0.89 EGFR (0.58) EGFRALKINSRIGF1R
SCHEMBL30936774 0.89 EGFR (0.69) EGFRALKINSRIGF1R
SCHEMBL30936923 0.88 EGFR (0.67) EGFRALK
SCHEMBL30937071 0.87 EGFR (0.63) EGFR
SCHEMBL30936850 0.86 EGFR (0.67) EGFR
SCHEMBL30936763 0.86 EGFR (0.69) EGFR
SCHEMBL30936939 0.86 EGFR (0.65) EGFRALKINSRIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024072178-A1 COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF (주)사이러스테라퓨틱스 2024-04-04 — — WO disclosed
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