Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 12/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937726 | 0.87 | GPR139 (0.48) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937598 | 0.86 | GPR139 (0.45) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937645 | 0.86 | GPR139 (0.47) | ACEMMP13GPR139MAPK1PER2 | |
| SCHEMBL30937564 | 0.85 | GPR139 (0.44) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937603 | 0.85 | GPR139 (0.42) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937710 | 0.84 | MAPK1 (0.47) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937708 | 0.84 | GPR139 (0.43) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937530 | 0.83 | GPR139 (0.42) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937625 | 0.82 | GPR139 (0.45) | ACEMMP13GPR139MAPK1 | |
| SCHEMBL30937644 | 0.80 | GPR139 (0.45) | ACEMMP13GPR139MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |