Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 12/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937726 | 0.90 | GPR139 (0.48) | GPR139MAPK1ACEMMP13 | |
| SCHEMBL30937710 | 0.89 | MAPK1 (0.47) | GPR139MAPK1ACEMMP13 | |
| SCHEMBL30937603 | 0.86 | GPR139 (0.42) | GPR139MAPK1ACEMMP13NTRK1 | |
| SCHEMBL30937611 | 0.82 | ACE (0.47) | GPR139MAPK1ACEMMP13 | |
| SCHEMBL30937598 | 0.81 | GPR139 (0.45) | GPR139MAPK1ACEMMP13 | |
| SCHEMBL30937648 | 0.81 | GPR139 (0.43) | GPR139MAPK1 | |
| SCHEMBL30937645 | 0.80 | GPR139 (0.47) | GPR139MAPK1ACEMMP13NTRK1 | |
| SCHEMBL30937631 | 0.79 | JAK2 (0.39) | GPR139MAPK1ACEMMP13JAK2 | |
| SCHEMBL30937564 | 0.79 | GPR139 (0.44) | GPR139MAPK1ACEMMP13 | |
| SCHEMBL30937532 | 0.79 | GPR139 (0.40) | GPR139MAPK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |