Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937524 | 0.86 | ACE (0.44) | ACEMMP13LMNAKDM4EALDH1A1 | |
| SCHEMBL30937712 | 0.86 | ACE (0.43) | ACEMMP13KDM4EALDH1A1CYP3A4 | |
| SCHEMBL30937672 | 0.82 | ACE (0.41) | ACEMMP13KDM4EALDH1A1CYP3A4 | |
| SCHEMBL31120591 | 0.78 | ACE (0.45) | ACEMMP13KDM4EALDH1A1CYP3A4 | |
| SCHEMBL30937651 | 0.78 | ACE (0.53) | ACEMMP13LMNAKDM4EALDH1A1 | |
| SCHEMBL30937691 | 0.74 | ACE (0.43) | ACEMMP13KDM4EALDH1A1CYP3A4 | |
| SCHEMBL30937732 | 0.72 | ACE (0.44) | ACEMMP13KDM4EALDH1A1CYP3A4 | |
| SCHEMBL30937538 | 0.72 | PER2 (0.45) | KDM4EALDH1A1CYP3A4HTTHPGD | |
| SCHEMBL30937727 | 0.71 | ACE (0.35) | ACEMMP13LMNAKDM4EALDH1A1 | |
| SCHEMBL30937679 | 0.68 | BRD4 (0.51) | ACEMMP13KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |