Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PTH1R | Q03431 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979096 | 1.00 | HSD11B1 (0.38) | HSD11B1HSD11B2PTGDR2PTH1RELANE | |
| SCHEMBL30939574 | 0.89 | AR (0.41) | HSD11B1HSD11B2PTGDR2PTH1RCYP11B2 | |
| SCHEMBL1979977 | 0.89 | AR (0.41) | HSD11B1HSD11B2PTGDR2PTH1RCYP11B2 | |
| SCHEMBL1979370 | 0.84 | ELANE (0.35) | HSD11B1HSD11B2ELANEARTRPV4 | |
| SCHEMBL30939539 | 0.84 | ELANE (0.35) | HSD11B1HSD11B2ELANEARTRPV4 | |
| SCHEMBL30939605 | 0.83 | SLC22A12 (0.37) | HSD11B1HSD11B2ARHRH3 | |
| SCHEMBL1984305 | 0.83 | SLC22A12 (0.37) | HSD11B1HSD11B2ARHRH3 | |
| SCHEMBL18952976 | 0.83 | HSD11B1 (0.34) | HSD11B1HSD11B2ELANEARTRPV4 | |
| SCHEMBL22026251 | 0.82 | GRIN1 (0.34) | HSD11B1HSD11B2PTH1RELANECYP11B2 | |
| SCHEMBL18952943 | 0.82 | PTGDR2 (0.37) | HSD11B1HSD11B2PTGDR2PTH1RCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118267386-A | Modulators of KV3 channels for the treatment of pain | 奥提芙尼治疗学有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-108472288-B | Modulators of KV3 channels for the treatment of pain | 奥提芙尼治疗学有限公司 | 2024-05-28 | — | — | CN | disclosed |