Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952956 | 0.90 | ELANE (0.33) | HSD11B1HSD11B2ELANEEGLN2SLC6A4 | |
| SCHEMBL30939539 | 0.84 | ELANE (0.35) | HSD11B1HSD11B2ELANETRPV4AR | |
| SCHEMBL1979370 | 0.84 | ELANE (0.35) | HSD11B1HSD11B2ELANETRPV4AR | |
| SCHEMBL1979096 | 0.83 | HSD11B1 (0.38) | HSD11B1HSD11B2ELANETRPV4AR | |
| SCHEMBL30939616 | 0.83 | HSD11B1 (0.38) | HSD11B1HSD11B2ELANETRPV4AR | |
| SCHEMBL1984809 | 0.83 | AR (0.43) | HSD11B1HSD11B2ELANETRPV4AR | |
| SCHEMBL18952958 | 0.80 | KDM4E (0.33) | HSD11B1ELANEARSLC6A4KCNH2 | |
| SCHEMBL1979251 | 0.76 | AR (0.35) | AR | |
| SCHEMBL1980366 | 0.76 | AR (0.36) | AR | |
| SCHEMBL13720513 | 0.75 | AR (0.44) | HSD11B1HSD11B2AREGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |