Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30940512 | 0.92 | TYK2 (0.41) | TYK2JAK1LMNASMN1; SMN2RAB9A | |
| SCHEMBL30940528 | 0.78 | TYK2 (0.45) | TYK2JAK1LMNASMN1; SMN2RAB9A | |
| SCHEMBL30940487 | 0.77 | TYK2 (0.39) | TYK2JAK1LMNASMN1; SMN2RAB9A | |
| SCHEMBL21002217 | 0.73 | GRM5 (0.44) | LMNASMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL30940532 | 0.73 | GRM5 (0.44) | LMNASMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL30204950 | 0.70 | CCNA2 (0.33) | LRRK2 | |
| SCHEMBL22290209 | 0.70 | CCNA2 (0.33) | LRRK2 | |
| SCHEMBL30940517 | 0.70 | TYK2 (0.53) | TYK2JAK1LMNAJAK2JAK3 | |
| SCHEMBL30940505 | 0.69 | GCK (0.39) | TYK2JAK1LMNASMN1; SMN2RAB9A | |
| SCHEMBL29260143 | 0.69 | GCK (0.39) | TYK2JAK1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315737-B | Heteroaryl compounds substituted with sulfone pyridinylalkylamides | 百时美施贵宝公司 | 2024-06-18 | — | — | CN | disclosed |