Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985227 | 0.82 | TYK2 (0.48) | TYK2JAK1CA12CA1CA2 | |
| SCHEMBL30940512 | 0.79 | TYK2 (0.41) | TYK2JAK1LMNASMN1; SMN2NPC1 | |
| SCHEMBL30940530 | 0.77 | TYK2 (0.39) | TYK2JAK1JAK2JAK3LMNA | |
| SCHEMBL30940499 | 0.74 | TYK2 (0.44) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL20985238 | 0.74 | TYK2 (0.61) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL30940531 | 0.74 | TYK2 (0.61) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL30940528 | 0.74 | TYK2 (0.45) | TYK2JAK1JAK2JAK3LMNA | |
| SCHEMBL30940481 | 0.72 | TYK2 (0.46) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL30617400 | 0.72 | TYK2 (0.63) | TYK2JAK1JAK2JAK3KCNH2 | |
| SCHEMBL24587279 | 0.71 | TYK2 (0.48) | TYK2JAK1JAK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315737-B | Heteroaryl compounds substituted with sulfone pyridinylalkylamides | 百时美施贵宝公司 | 2024-06-18 | — | — | CN | disclosed |