Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218212 | 0.87 | RXFP1 (0.49) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL25405454 | 0.79 | GAA (0.72) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3083725 | 0.78 | POLB (0.38) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL12309834 | 0.74 | RAB9A (0.57) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3045369 | 0.73 | RAB9A (0.59) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL5346367 | 0.73 | PSEN1 (0.61) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL28340102 | 0.72 | ALDH1A1 (0.68) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL25302814 | 0.72 | ALDH1A1 (0.65) | MEN1KMT2AALDH1A1HPGDRAB9A | |
| SCHEMBL25301409 | 0.72 | ALDH1A1 (0.54) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL25252900 | 0.72 | ALDH1A1 (0.54) | POLBMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795289-B2 | Use of acylaminothiazole derivatives as therapeutic agents | SANOFI-AVENTIS (FR) | 2010-09-14 | — | — | US | disclosed |
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | SANOFI-AVENTIS (FR) | 2008-02-28 | — | — | US | disclosed |
| US-7291636-B2 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-11-06 | — | — | US | disclosed |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | BACE1, BACE2, ATG4A | POLB 1718/4885MEN1 3225/4885KMT2A 1723/4885 |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | BACE1, APP, BACE2 | POLB 1906/4885MEN1 2658/4885KMT2A 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.