Sugi Predict

Sugi Predict / Compounds / Pyridine

Pyridine

Pyridine

SCHEMBL3094623

Fc1cnc2[nH]ccc2c1Cl.c1ccncc1

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKCI P41743 4/20 0.51
▸ AXL P30530 2/20 0.51
▸ NUDT1 P36639 4/20 0.47
▸ JAK2 O60674 2/20 0.40
▸ IKBKB O14920 1/20 0.40
▸ CHUK O15111 1/20 0.40
▸ DAPK3 O43293 1/20 0.40
▸ PRKD3 O94806 1/20 0.40
▸ MAP4K4 O95819 1/20 0.40
▸ PAK4 O96013 1/20 0.40
▸ CSF1R P07333 1/20 0.40
▸ RET P07949 1/20 0.40
▸ IGF1R P08069 1/20 0.40
▸ FGFR1 P11362 1/20 0.40
▸ PRKACA P17612 1/20 0.40
▸ FLT1 P17948 1/20 0.40
▸ LTK P29376 1/20 0.40
▸ GRK5 P34947 1/20 0.40
▸ KDR P35968 1/20 0.40
▸ MAP2K2 P36507 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29431105 0.89 PRKCI (0.62) PRKCIAXLNUDT1JAK2DAPK3
SCHEMBL1749025 0.89 PRKCI (0.62) PRKCIAXLNUDT1JAK2DAPK3
SCHEMBL30173327 0.72 NUDT1 (0.68) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL30173320 0.72 NUDT1 (0.68) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL28602236 0.72 NUDT1 (0.68) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL1467759 0.71 NUDT1 (0.50) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL29660498 0.71 NUDT1 (0.50) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL1356886 0.71 PRKCI (0.67) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL2105056 0.71 TTBK1 (0.53) PRKCIAXLNUDT1JAK2IKBKB
SCHEMBL3725709 0.70 JAK2 (0.58) PRKCIAXLNUDT1JAK2IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799691-B1 NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2011-12-21 — — EP disclosed
US-20100256141-A1 NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2010-10-07 — — US disclosed
US-20080045561-A1 Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors AVENTIS PHARMA S.A. (FR) 2008-02-21 — — US disclosed
EP-1799691-A1 NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2007-06-27 — — EP disclosed
WO-2006037875-A1 NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2006-04-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045561-A1 Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors BRSK2, KSR2, CDK2 PRKCI 209/4885AXL 636/4885NUDT1 1898/4885
US-20100256141-A1 NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS BRSK2, KSR2, CDK2 PRKCI 209/4885AXL 636/4885NUDT1 1898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.