Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 7/20 | 0.71 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948269 | 0.85 | IL4I1 (0.69) | IL4I1PRMT5HSD11B1TNIK | |
| SCHEMBL30948031 | 0.84 | IL4I1 (0.68) | IL4I1CYP11B1CYP11B2PRMT5TNIK | |
| SCHEMBL30947973 | 0.83 | IL4I1 (1.00) | IL4I1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL27163434 | 0.81 | IL4I1 (0.62) | IL4I1HSD11B1TNIKDHPSSMN1; SMN2 | |
| SCHEMBL30947994 | 0.80 | IL4I1 (0.53) | IL4I1HSD11B1 | |
| SCHEMBL30947916 | 0.80 | IL4I1 (0.61) | IL4I1CYP11B1TNIKDHPSNPSR1 | |
| SCHEMBL30948291 | 0.78 | IL4I1 (0.65) | IL4I1LMNASMN1; SMN2MEN1NPC1 | |
| SCHEMBL30948147 | 0.77 | IL4I1 (0.50) | IL4I1HSD11B1 | |
| SCHEMBL30948375 | 0.77 | IL4I1 (0.64) | IL4I1CYP11B1CYP11B2LMNASMN1; SMN2 | |
| SCHEMBL30947930 | 0.76 | IL4I1 (0.62) | IL4I1CYP11B1CYP11B2PRMT5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | IL4I1, IL4, IL2 | IL4I1 1/4885CYP11B1 1150/4885CYP11B2 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.