Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27865683 | 0.73 | POLB (0.46) | ALDH1A1PTGS2HPGDPTGDR2 | |
| SCHEMBL18136496 | 0.71 | BRD4 (0.49) | ALDH1A1KDM4ESMN1; SMN2GAAALOX15 | |
| SCHEMBL15717101 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2GAAALOX15 | |
| SCHEMBL13685103 | 0.68 | PTGS2 (0.49) | ALDH1A1SMN1; SMN2PTGS2PTGDR2MEN1 | |
| SCHEMBL8774870 | 0.68 | PTGDR2 (0.47) | ALDH1A1KDM4ESMN1; SMN2CAMKK1CAMKK2 | |
| SCHEMBL30215707 | 0.67 | MEN1 (0.45) | PTGS2PTGDR2MEN1KMT2A | |
| SCHEMBL28136045 | 0.67 | PTPN5 (0.41) | KDM4EPTGS2GAAPTGDR2 | |
| SCHEMBL18134415 | 0.67 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2GAAALOX15 | |
| SCHEMBL25799378 | 0.67 | POLB (0.41) | ALDH1A1KDM4EPTGS2GAAHPGD | |
| SCHEMBL11126671 | 0.67 | PDCD1 (0.42) | ALDH1A1KDM4ESMN1; SMN2PTGS2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240245681-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBO PHARMACEUTICATS CO LTD (CN) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240245681-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN1, PTPN5, PTPN2 | ALDH1A1 2877/4885KDM4E 685/4885SMN1; SMN2 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.