Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | RHOC | P08134 | 2/20 | 0.41 |
| ▸ | RHOA | P61586 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094854 | 1.00 | CES2 (0.53) | CES2HIF1ACYP3A4USP2TSHR | |
| SCHEMBL3096904 | 0.79 | CES2 (0.50) | CES2HIF1ACYP3A4USP2TSHR | |
| SCHEMBL3091750 | 0.77 | CES2 (0.48) | CES2HIF1ACYP3A4USP2TSHR | |
| SCHEMBL13156507 | 0.76 | CES2 (0.47) | CES2HIF1ACYP3A4USP2TSHR | |
| SCHEMBL3094810 | 0.75 | CYP3A4 (0.47) | CES2CYP3A4USP2TSHRCYP2C9 | |
| SCHEMBL3094820 | 0.75 | CYP3A4 (0.47) | CES2CYP3A4USP2TSHRCYP2C9 | |
| SCHEMBL13753509 | 0.73 | HPGD (0.56) | HIF1ACYP3A4USP2TSHRCYP2C19 | |
| SCHEMBL30691966 | 0.72 | HIF1A (0.46) | CES2HIF1ACYP3A4USP2TSHR | |
| SCHEMBL96116 | 0.71 | CES2 (0.67) | CES2HIF1ANOTUMGAAMAPT | |
| SCHEMBL16180051 | 0.71 | CES2 (0.73) | CES2HIF1ANOTUMGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799934-B2 | Intermediates (synthons) in the synthesis of pharmaceuticals such as oseltamivir and other products; treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-09-21 | — | — | US | disclosed |
| US-20090030212-A1 | Enantioselective ring-opening of aziridines | UNIVERSITY OF SOUTH FLORIDA OF TAMPA | 2009-01-29 | — | — | US | disclosed |
| WO-2009005775-A2 | ENANTIOSELECTIVE RING-OPENING OF AZIRIDINES | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030212-A1 | Enantioselective ring-opening of aziridines | AZI2, ITPA, ADORA2A | CES2 3526/4885HIF1A 4306/4885CYP3A4 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.