Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948584 | 1.00 | EGFR (0.53) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL30948623 | 0.93 | EGFR (0.50) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL30948582 | 0.93 | EGFR (0.50) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL30948615 | 0.88 | ALK (0.55) | EGFRALKAURKAINSRIGF1R | |
| SCHEMBL22246247 | 0.87 | EGFR (0.52) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL30948600 | 0.87 | EGFR (0.49) | EGFRALKMAPK9MAPK10MAPK8 | |
| SCHEMBL22520091 | 0.87 | EGFR (0.60) | EGFRALKAURKAINSRIGF1R | |
| SCHEMBL22246279 | 0.85 | EGFR (0.60) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL22246241 | 0.84 | EGFR (0.49) | EGFRALKAXLMAPK9MAPK10 | |
| SCHEMBL30948622 | 0.83 | EGFR (0.59) | EGFRALKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677680-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |