Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNK | O75909 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28662985 | 0.88 | EGFR (0.65) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL28662982 | 0.88 | EGFR (0.65) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL30948591 | 0.81 | MAPK9 (0.44) | EGFRBRD4ALKMAPK9MAPK10 | |
| SCHEMBL28665507 | 0.78 | MAPK9 (0.46) | BRD4ALKCCNA2CDK2CCNK | |
| SCHEMBL29190558 | 0.78 | ULK1 (0.45) | BRD4ALKCCNA2CDK2CCNK | |
| SCHEMBL28667751 | 0.76 | EGFR (0.68) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL29783086 | 0.76 | EGFR (0.68) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL30948585 | 0.76 | CCNK (0.52) | EGFRBRD4ALKCCNA2CDK2 | |
| SCHEMBL28648152 | 0.76 | EGFR (0.84) | EGFRINSRIGF1RALKFGFR1 | |
| SCHEMBL22520094 | 0.74 | EGFR (0.65) | EGFRINSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677680-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |