Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329249 | 0.82 | HPGD (0.52) | TSHRHSD11B1SIRT3TDP1ALDH1A1 | |
| SCHEMBL27978853 | 0.77 | L3MBTL1 (0.59) | TSHRHSD11B1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10720319 | 0.77 | L3MBTL1 (0.60) | TSHRHSD11B1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL24941110 | 0.74 | SIRT3 (0.54) | SIRT3TDP1KMT2A | |
| SCHEMBL4560910 | 0.74 | L3MBTL1 (0.50) | TSHRHSD11B1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL10722280 | 0.74 | HSD11B1 (0.70) | TSHRHSD11B1L3MBTL1MEN1KMT2A | |
| SCHEMBL5430953 | 0.73 | TSHR (0.54) | TSHRHSD11B1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL9001748 | 0.71 | TSHR (0.68) | TSHRHSD11B1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1354645 | 0.71 | HSD11B1 (0.53) | TSHRHSD11B1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL1355140 | 0.71 | HSD11B1 (0.50) | TSHRHSD11B1L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | TSHR 3631/4885HSD11B1 1099/4885SIRT3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.