Potassium

Potassium

SCHEMBL30957778

COc1cc(-c2cc(F)cc(C(C)C)c2CC(=O)NS(=O)(=O)c2ccc(C(C)(C)N(C)C)c(F)c2)ccn1.[K]

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 18/20 0.63
LIPG Q9Y5X9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22867032 0.99 NLRP3 (0.64) NLRP3LIPG
Potassium SCHEMBL30957790 0.92 NLRP3 (0.63) NLRP3
SCHEMBL22867163 0.91 NLRP3 (0.64) NLRP3
SCHEMBL22866873 0.90 NLRP3 (0.63) NLRP3LIPG
SCHEMBL22867030 0.89 NLRP3 (0.62) NLRP3
SCHEMBL22867096 0.89 NLRP3 (0.62) NLRP3
Potassium SCHEMBL30957789 0.87 NLRP3 (0.63) NLRP3
SCHEMBL22867147 0.87 NLRP3 (0.64) NLRP3
SCHEMBL22867031 0.86 NLRP3 (0.59) NLRP3
SCHEMBL30957780 0.86 NLRP3 (0.59) NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors INFLAZOME LIMITED (IE) 2024-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors NLRP3, NOD1, NLRP1 NLRP3 1/4885LIPG 3751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.