Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055516 | 0.83 | IDO1 (0.53) | IDO1NOS1AXLMETAP2MET | |
| SCHEMBL30135663 | 0.79 | IDO1 (0.51) | IDO1NOS1AXLMETAP2MET | |
| SCHEMBL26259570 | 0.78 | CACNA2D1 (0.36) | — | |
| SCHEMBL12405326 | 0.77 | CACNA2D1 (0.35) | — | |
| SCHEMBL30135671 | 0.75 | IDO1 (0.47) | IDO1NOS1AXLMETAP2MET | |
| SCHEMBL25238925 | 0.75 | ALK (0.40) | JAK2BRD4 | |
| SCHEMBL31140667 | 0.75 | ALK (0.40) | JAK2BRD4 | |
| SCHEMBL29977301 | 0.72 | GRM5 (0.45) | — | |
| SCHEMBL26259230 | 0.72 | GRM5 (0.45) | — | |
| SCHEMBL12525231 | 0.72 | NOS1 (0.46) | IDO1NOS1AXLMETAP2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615847-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024103010-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-05-16 | — | — | WO | disclosed |