Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30959666 | 0.79 | LMNA (0.35) | CHRM4LMNAMAPT | |
| SCHEMBL21048234 | 0.70 | CHRM4 (0.40) | CHRM4LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL21523134 | 0.69 | CHRM4 (0.46) | CHRM4CYP3A4 | |
| SCHEMBL30383437 | 0.69 | CHRM4 (0.46) | CHRM4CYP3A4 | |
| SCHEMBL21146605 | 0.68 | CHRM4 (0.38) | CHRM4LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL30959629 | 0.68 | L3MBTL1 (0.37) | CHRM4LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL30959274 | 0.68 | — | — | |
| SCHEMBL23775116 | 0.65 | CHRM4 (0.35) | CHRM4LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL30366781 | 0.65 | CHRM4 (0.35) | CHRM4LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL21523124 | 0.64 | CHRM4 (0.44) | CHRM4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709371-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2025235740-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2025-11-13 | — | — | WO | disclosed |
| EP-4615847-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024233776-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME LLC (US) | 2024-11-14 | — | — | WO | disclosed |
| WO-2024103010-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-05-16 | — | — | WO | disclosed |