Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25305805 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGDKITPDGFRA | |
| SCHEMBL25642895 | 0.84 | ALDH1A1 (0.36) | ALDH1A1KDM4EKITPDGFRAFLT4 | |
| SCHEMBL31650059 | 0.84 | ALDH1A1 (0.36) | ALDH1A1KDM4EKITPDGFRAFLT4 | |
| SCHEMBL31048409 | 0.84 | ALDH1A1 (0.36) | ALDH1A1KDM4EKITPDGFRAFLT4 | |
| SCHEMBL30550465 | 0.76 | EGFR (0.42) | ALDH1A1KDM4EKITPDGFRAFLT4 | |
| SCHEMBL25307258 | 0.76 | EGFR (0.42) | ALDH1A1KDM4EKITPDGFRAFLT4 | |
| SCHEMBL31650459 | 0.76 | EGFR (0.36) | ALDH1A1KITPDGFRAFLT4KDR | |
| SCHEMBL34461299 | 0.74 | PGR (0.43) | ALDH1A1KDM4EMAPTMAPK1KMT2A | |
| SCHEMBL11971460 | 0.73 | MAPT (0.55) | ALDH1A1KDM4EHPGDMAPTMAPK1 | |
| SCHEMBL1806126 | 0.73 | MAPT (0.55) | ALDH1A1KDM4EHPGDMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |