Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 9/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30694876 | 0.76 | CHRNB4 (0.36) | IDH1HRH3KCNH2 | |
| SCHEMBL21590964 | 0.73 | PDE3B (0.38) | IDH1HRH3KCNH2ACACB | |
| SCHEMBL23490426 | 0.71 | PIM1 (0.47) | — | |
| SCHEMBL20008968 | 0.70 | ACACB (0.50) | HRH3KCNH2ACACB | |
| SCHEMBL23573230 | 0.69 | SCD5 (0.38) | — | |
| SCHEMBL23573229 | 0.69 | SCD5 (0.38) | — | |
| SCHEMBL30961923 | 0.69 | POLB (0.46) | HRH3KCNH2 | |
| SCHEMBL1588164 | 0.68 | POLB (0.50) | — | |
| SCHEMBL30694880 | 0.68 | MAPT (0.43) | — | |
| SCHEMBL29618503 | 0.67 | ACACB (0.37) | HRH3ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149933-B1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN LA ROCHE (CH) | 2024-06-12 | — | — | EP | claimed |