Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761331 | 0.98 | ALDH1A1 (0.47) | POLBALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL5757671 | 0.85 | CHRNB2 (0.53) | HTR3ACHRNB2CHRNA4CHRNA1CHRNA7 | |
| Hydrochloric Acid SCHEMBL4812347 | 0.84 | CHRNB2 (0.51) | HTR3ACHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL1588164 | 0.84 | POLB (0.50) | POLBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL5759446 | 0.84 | ALDH1A1 (0.47) | POLBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL31574277 | 0.76 | SYK (0.41) | CHRNB2CHRNA4KCNH2 | |
| SCHEMBL30961905 | 0.75 | TIPARP (0.51) | POLBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL21590997 | 0.72 | NAMPT (0.32) | — | |
| SCHEMBL19211078 | 0.70 | KDM4E (0.46) | POLBMAPTHTR3ACHRNB2CHRNA4 | |
| SCHEMBL21590964 | 0.70 | PDE3B (0.38) | HTR3ACHRNB2CHRNA4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149933-B1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN LA ROCHE (CH) | 2024-06-12 | — | — | EP | claimed |