SCHEMBL30962685

SCHEMBL30962685

COc1nc(Nc2ccc(OC3CCN(C)C3)c(C)c2)ncc1C(=O)Nc1c(Cl)ccc(O[Si](C)(C)C(C)(C)C)c1C

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 4/20 0.38
▸ LCK P06239 2/20 0.38
▸ KDR P35968 1/20 0.38
▸ JAK3 P52333 1/20 0.38
▸ TEK Q02763 1/20 0.38
▸ MAPK14 Q16539 1/20 0.38
▸ BRD4 O60885 4/20 0.37
▸ TTK P33981 1/20 0.37
▸ PTK2 Q05397 4/20 0.37
▸ AXL P30530 1/20 0.37
▸ TYRO3 Q06418 1/20 0.37
▸ MERTK Q12866 1/20 0.37
▸ SIK1 P57059 2/20 0.37
▸ SIK2 Q9H0K1 2/20 0.37
▸ SIK3 Q9Y2K2 2/20 0.37
▸ UTS2R Q9UKP6 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30962750 0.97 TTK (0.40) SRCLCKKDRJAK3TEK
SCHEMBL30962942 0.89 SRC (0.41) SRCLCKKDRJAK3TEK
SCHEMBL30962674 0.89 SRC (0.41) SRCLCKKDRJAK3TEK
SCHEMBL30962908 0.89 WEE1 (0.43) SRCLCKKDRJAK3TEK
SCHEMBL30962907 0.88 SRC (0.47) SRCLCKKDRJAK3TEK
SCHEMBL30962759 0.88 SRC (0.47) SRCLCKKDRJAK3TEK
SCHEMBL30962748 0.86 SRC (0.44) SRCLCKKDRJAK3TEK
SCHEMBL30962895 0.86 SRC (0.44) SRCLCKKDRJAK3TEK
SCHEMBL30962681 0.86 TTK (0.43) SRCLCKKDRJAK3TEK
SCHEMBL30962922 0.84 WEE1 (0.44) SRCLCKKDRJAK3TEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4642767-A1 PYRIMIDINE CARBOXAMIDE COMPOUNDS Acrivon Therapeutics, Inc. (US) 2025-11-05 — — EP disclosed
WO-2024145505-A1 PYRIMIDINE CARBOXAMIDE COMPOUNDS ACRIVON THERAPEUTICS, INC. (US) 2024-07-04 — — WO disclosed
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