SCHEMBL30962748

SCHEMBL30962748

COc1nc(Nc2ccc(OC3CCN(C)C3)c(C)c2)ncc1C(=O)Nc1c(Cl)cccc1Br

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 8/20 0.44
▸ TTK P33981 1/20 0.42
▸ SIK1 P57059 2/20 0.42
▸ SIK2 Q9H0K1 2/20 0.42
▸ SIK3 Q9Y2K2 2/20 0.42
▸ FGFR1 P11362 2/20 0.41
▸ HCK P08631 1/20 0.41
▸ LCK P06239 3/20 0.41
▸ KDR P35968 2/20 0.41
▸ JAK3 P52333 1/20 0.41
▸ TEK Q02763 1/20 0.41
▸ MAPK14 Q16539 1/20 0.41
▸ ERBB2 P04626 1/20 0.41
▸ EPHA2 P29317 1/20 0.41
▸ EPHB4 P54760 1/20 0.41
▸ PTK2 Q05397 2/20 0.41
▸ EGFR P00533 1/20 0.40
▸ SCN9A Q15858 1/20 0.40
▸ MAP4K1 Q92918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30962895 1.00 SRC (0.44) SRCTTKSIK1SIK2SIK3
SCHEMBL30962930 0.96 SRC (0.46) SRCTTKSIK1SIK2SIK3
SCHEMBL30962929 0.96 SRC (0.46) SRCTTKSIK1SIK2SIK3
SCHEMBL30962759 0.95 SRC (0.47) SRCTTKSIK1SIK2SIK3
SCHEMBL30962907 0.95 SRC (0.47) SRCTTKSIK1SIK2SIK3
SCHEMBL30962820 0.90 SRC (0.47) SRCTTKSIK1SIK2SIK3
SCHEMBL30962749 0.90 PIK3CD (0.43) SRCTTKERBB2EGFR
SCHEMBL30962731 0.89 SRC (0.44) SRCTTKLCKPTK2MAP4K1
SCHEMBL30962709 0.89 TNK2 (0.43) SRCFGFR1LCKJAK3PTK2
SCHEMBL30962935 0.89 WEE1 (0.46) SRCSIK1SIK2SIK3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4642767-A1 PYRIMIDINE CARBOXAMIDE COMPOUNDS Acrivon Therapeutics, Inc. (US) 2025-11-05 — — EP disclosed
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