Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29242289 | 1.00 | TP53 (0.49) | TP53MAPTPOLBNQO2LMNA | |
| SCHEMBL29242291 | 0.89 | MAPT (0.40) | TP53MAPTPOLBNQO2AGTR1 | |
| SCHEMBL30965344 | 0.83 | PGR (0.41) | TP53MAPTPOLBALDH1A1CYP1A2 | |
| SCHEMBL29242350 | 0.83 | PGR (0.41) | TP53MAPTPOLBALDH1A1CYP1A2 | |
| SCHEMBL29242344 | 0.82 | TP53 (0.48) | TP53MAPTPOLBNQO2LMNA | |
| SCHEMBL30965340 | 0.82 | TP53 (0.48) | TP53MAPTPOLBNQO2LMNA | |
| SCHEMBL29242355 | 0.77 | BRD4 (0.41) | TP53MAPTPOLBALDH1A1CYP1A2 | |
| SCHEMBL30965343 | 0.77 | BRD4 (0.41) | TP53MAPTPOLBALDH1A1CYP1A2 | |
| SCHEMBL30965336 | 0.75 | BRD4 (0.47) | TP53MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL29242303 | 0.75 | BRD4 (0.47) | TP53MAPTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221565-A | 3-Aryl indol-2-one compound with anticancer activity and application thereof in preparation of medicines for treating cancers | 常州大学 | 2024-06-21 | — | — | CN | disclosed |