Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.68 |
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | TYK2 | P29597 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965374 | 0.92 | EGFR (0.70) | EGFRALKINSRIGF1R | |
| SCHEMBL30556273 | 0.88 | EGFR (0.75) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL22104574 | 0.88 | EGFR (0.75) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL30965380 | 0.87 | EGFR (0.67) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL30965394 | 0.86 | ALK (0.69) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL26875434 | 0.84 | JAK2 (0.65) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL30965382 | 0.82 | ALK (0.82) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL30556299 | 0.78 | EGFR (0.60) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL22104389 | 0.78 | EGFR (0.60) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL22104578 | 0.77 | EGFR (0.62) | EGFRJAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221696-A | Pyrimidine heterocyclic compound containing N-methylpiperazine structure, and preparation method and application thereof | 潍坊医学院 | 2024-06-21 | — | — | CN | disclosed |