Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.69 |
| ▸ | INSR | P06213 | 15/20 | 0.69 |
| ▸ | IGF1R | P08069 | 15/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | MET | P08581 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | STK10 | O94804 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | FES | P07332 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | YES1 | P07947 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965382 | 0.92 | ALK (0.82) | ALKINSRIGF1REGFRMET | |
| SCHEMBL30965381 | 0.86 | EGFR (0.68) | ALKINSRIGF1REGFRJAK2 | |
| SCHEMBL30965392 | 0.85 | ALK (0.66) | ALKINSRIGF1REGFRMET | |
| SCHEMBL26906542 | 0.82 | ALK (0.65) | ALKINSRIGF1REGFRMET | |
| SCHEMBL26089861 | 0.82 | ALK (1.00) | ALKINSRIGF1REGFRMET | |
| SCHEMBL30965374 | 0.81 | EGFR (0.70) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26087740 | 0.81 | ALK (0.86) | ALKINSRIGF1REGFRMET | |
| SCHEMBL30377906 | 0.81 | ALK (0.86) | ALKINSRIGF1REGFRMET | |
| SCHEMBL18696328 | 0.80 | INSR (0.75) | ALKINSRIGF1REGFRMET | |
| SCHEMBL19312802 | 0.80 | ALK (0.83) | ALKINSRIGF1REGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221696-A | Pyrimidine heterocyclic compound containing N-methylpiperazine structure, and preparation method and application thereof | 潍坊医学院 | 2024-06-21 | — | — | CN | disclosed |