Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29236666 | 1.00 | HTT (0.56) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL3940426 | 0.87 | HTT (0.61) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL30969381 | 0.87 | LMNA (0.64) | HTTLMNAMAPK1NPC1TUBB1 | |
| SCHEMBL29236859 | 0.87 | LMNA (0.64) | HTTLMNAMAPK1NPC1TUBB1 | |
| SCHEMBL29236927 | 0.86 | TUBB1 (0.53) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL29689805 | 0.86 | TUBB1 (0.53) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL1515704 | 0.84 | HTT (0.62) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL29236861 | 0.84 | LMNA (0.54) | HTTLMNAMAPK1NPC1TUBB1 | |
| SCHEMBL1347457 | 0.83 | HTT (0.68) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL17507494 | 0.83 | TUBB1 (0.65) | HTTLMNAMAPK1NPC1TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573490-B | Diaryl-2H-aziridine compounds, preparation method and application thereof | 复旦大学 | 2024-04-30 | — | — | CN | disclosed |