Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15141956 | 0.79 | — | — | |
| SCHEMBL5793769 | 0.72 | — | — | |
| SCHEMBL5138845 | 0.69 | KMT2A (0.41) | DYRK1APKN1PKN2 | |
| SCHEMBL8343167 | 0.68 | MAP2K1 (0.43) | CDC7CDK9CDK2PLK1CDK1 | |
| SCHEMBL23691776 | 0.65 | ALDH1A1 (0.35) | CDC7 | |
| SCHEMBL24852286 | 0.65 | CRBN (0.35) | CDC7MAPKAPK2CDK9CDK2ROCK2 | |
| SCHEMBL23337429 | 0.64 | MEN1 (0.40) | MAPK1 | |
| SCHEMBL3399674 | 0.63 | PARP10 (0.53) | PARP1PDPK1PARP10PARP11 | |
| SCHEMBL30097771 | 0.62 | MKNK1 (0.40) | CDC7MAPKAPK2CLK4MKNK1DAPK3 | |
| SCHEMBL8309980 | 0.62 | MAP2K1 (0.37) | CDC7MAPKAPK2CDK1PRKD3CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946098-A | Pyrimidine PLK1 inhibitor and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-04-30 | — | — | CN | disclosed |