Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923830 | 0.81 | MEN1 (0.42) | MEN1KMT2ABLMHTR1ADRD2 | |
| SCHEMBL23336559 | 0.78 | HTR1A (0.35) | MEN1KMT2ABLMHTR1ADRD2 | |
| SCHEMBL5793769 | 0.69 | — | — | |
| SCHEMBL5138845 | 0.66 | KMT2A (0.41) | MEN1KMT2ABLMHTR1ADRD2 | |
| SCHEMBL16188711 | 0.64 | MEN1 (0.36) | MEN1KMT2ABUB1ATAD2GRM5 | |
| SCHEMBL23337430 | 0.64 | ALDH1A1 (0.43) | MEN1KMT2AHTR1ADRD2HTR2A | |
| SCHEMBL30969607 | 0.64 | CDC7 (0.43) | MAPK1 | |
| SCHEMBL12082637 | 0.64 | AKT1 (0.39) | DRD2CYP2C19 | |
| SCHEMBL16626803 | 0.63 | GRM5 (0.33) | MEN1KMT2AALDH1A1GRM5 | |
| SCHEMBL2669115 | 0.63 | GRM5 (0.39) | MEN1KMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133894-A1 | BTK INHIBITORS | BIOGEN MA INC. (US) | 2021-07-01 | — | — | WO | disclosed |
| WO-2021087086-A1 | CONDENSED PYRIDAZINE OR PYRIMIDINE AS BTK INHIBITORS | BIOGEN MA INC. (US) | 2021-05-06 | — | — | WO | disclosed |