Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.56 |
| ▸ | BTK | Q06187 | 8/20 | 0.56 |
| ▸ | TEC | P42680 | 2/20 | 0.56 |
| ▸ | CD69 | Q07108 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | YES1 | P07947 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | HCK | P08631 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | CSK | P41240 | 1/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30970922 | 0.78 | BTK (0.51) | BTKLCKLYN | |
| SCHEMBL26541434 | 0.74 | BTK (0.82) | EGFRBTKTECCD69RIPK2 | |
| SCHEMBL18644879 | 0.73 | BTK (0.89) | EGFRBTKTECCD69RIPK2 | |
| SCHEMBL18285473 | 0.73 | JAK2 (0.40) | BTKJAK2JAK3JAK1 | |
| Tolebrutinib SCHEMBL29564612 | 0.72 | BTK (1.00) | EGFRBTKTECCD69RIPK2 | |
| Tolebrutinib SCHEMBL18285624 | 0.72 | BTK (1.00) | EGFRBTKTECCD69RIPK2 | |
| Tolebrutinib SCHEMBL18285621 | 0.72 | BTK (1.00) | EGFRBTKTECCD69RIPK2 | |
| Tolebrutinib SCHEMBL29999020 | 0.72 | BTK (1.00) | EGFRBTKTECCD69RIPK2 | |
| SCHEMBL18644867 | 0.72 | BTK (0.88) | EGFRBTKTECCD69RIPK2 | |
| SCHEMBL18644873 | 0.72 | BTK (0.88) | EGFRBTKTECCD69RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4637726-A1 | DRUG FORMULATIONS OF (R)-1-(1-ACRYLOYLPIPERIDIN-3-YL)-4-AMINO-3-(4- PHENOXYPHENYL)-1H-IMIDAZO[4,5-C]PYRIDIN-2(3H)-ONE | Principia Biopharma Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024137604-A1 | DRUG FORMULATIONS OF (R)-L-(L-ACRYLOYLPIPERIDIN-3-YL)-4-AMINO-3-(4- PHENOXYPHENYL)-1H-IMIDAZO[4,5-C]PYRIDIN-2(3H)-ONE | GENZYME CORPORATION (US) | 2024-06-27 | — | — | WO | disclosed |