Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3099733 | 1.00 | NPC1 (0.65) | NPC1LMNAHTTL3MBTL1RAB9A | |
| SCHEMBL457954 | 0.93 | NPC1 (0.73) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL5218244 | 0.87 | NPC1 (0.81) | NPC1LMNAL3MBTL1RAB9AMAPT | |
| SCHEMBL1420182 | 0.86 | NPC1 (0.65) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL6225326 | 0.86 | NPC1 (0.65) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL12637609 | 0.86 | NPC1 (0.65) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL6203838 | 0.85 | KMT2A (0.64) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL6201733 | 0.85 | NPC1 (0.63) | NPC1LMNAHTTL3MBTL1RAB9A | |
| SCHEMBL14157088 | 0.85 | CA1 (0.70) | NPC1LMNAHTTRAB9AMAPT | |
| SCHEMBL3099798 | 0.85 | NPC1 (0.63) | NPC1LMNAHTTL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822205-B2 | Deoxybenzoin-derived anti-flammable polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-21 | — | — | US | disclosed |
| US-9340635-B2 | Deoxybenzoin-derived anti-flammable polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2016-05-17 | — | — | US | disclosed |
| US-9265767-B2 | 1,2-disubstituted heterocyclic compounds | FORUM PHARMACEUTICALS INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20160009854-A1 | DEOXYBENZOIN-DERIVED ANTI-FLAMMABLE POLYMERS | UNIVERSITY OF MASSACHUSETTS | 2016-01-14 | — | — | US | disclosed |
| US-20160009841-A1 | DEOXYBENZOIN-DERIVED ANTI-FLAMMABLE POLYMERS | UNIVERSITY OF MASSACHUSETTS | 2016-01-14 | — | — | US | disclosed |
| US-9175131-B2 | Deoxybenzoin-derived anti-flammable polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150274706-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | FMR LLC | 2015-10-01 | — | — | US | disclosed |
| US-8933074-B2 | 1,2-disubstituted heterocyclic compounds | FORUM PHARMACEUTICALS INC. (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140011808-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | FMR LLC | 2014-01-09 | — | — | US | disclosed |
| US-8466148-B2 | 1,2-disubstituted heterocyclic compounds | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20130102754-A1 | DEOXYBENZOIN-DERIVED ANTI-FLAMMABLE POLYMERS | UNIVERSITY OF MASSACHUSETTS (US) | 2013-04-25 | — | — | US | disclosed |
| US-8314202-B2 | Deoxybenzoin-derived anti-flammable polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120232265-A1 | 1,2-Disubstituted Heterocyclic Compounds | ENVIVO PHARMACEUTICALS, INC. | 2012-09-13 | — | — | US | disclosed |
| US-20110112241-A1 | DEOXYBENZOIN-DERIVED ANTI-FLAMMABLE POLYMERS | UNIVERSITY OF MASSACHUSETTS | 2011-05-12 | — | — | US | disclosed |
| US-20100234395-A1 | UREIDE DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20100234395-A1 | UREIDE DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20100234395-A1 | UREIDE DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2010-09-16 | — | — | US | disclosed |
| EP-2009006-A1 | UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | TORAY INDUSTRIES, INC. (JP) | 2008-12-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232265-A1 | 1,2-Disubstituted Heterocyclic Compounds | PDE12, PDE7A, PDE10A | NPC1 2422/4885LMNA 3565/4885HTT 313/4885 |
| US-20140011808-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | PDE12, PDE7A, PDE10A | NPC1 2422/4885LMNA 3565/4885HTT 313/4885 |
| US-20150274706-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | PDE12, PDE7A, PDE10A | NPC1 2422/4885LMNA 3565/4885HTT 313/4885 |
| US-20100234395-A1 | UREIDE DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF | UROD, UTS2R, SLC14A1 | NPC1 1768/4885LMNA 3156/4885HTT 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.