Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22905751 | 0.77 | HTR2C (0.43) | HTR2CHTR2ADRD2LMNAMAPT | |
| SCHEMBL22905577 | 0.72 | HTR2C (0.40) | HTR2CHTR2ADRD2POLBHSD17B10 | |
| SCHEMBL30973541 | 0.68 | HTR2C (0.34) | HTR2CHTR2ADRD2POLBHSD17B10 | |
| SCHEMBL6101336 | 0.68 | HSD17B10 (0.49) | HTR2CHTR2ADRD2MAPTPOLB | |
| SCHEMBL13677130 | 0.67 | ACHE (0.46) | HTR2CPOLBHSD17B10GAAKDM4E | |
| SCHEMBL16663984 | 0.67 | HTR2C (0.48) | HTR2CDRD2LMNAMAPTPOLB | |
| SCHEMBL6024691 | 0.64 | BUB1 (0.38) | LMNAMAPTPOLBALDH1A1HTT | |
| SCHEMBL2840999 | 0.63 | KMT2A (0.43) | HTR2ALMNAMAPTPOLBALDH1A1 | |
| SCHEMBL3129135 | 0.62 | HSD17B10 (0.39) | HTR2CMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL333300 | 0.62 | MAPT (0.42) | HTR2CMAPTPOLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4642784-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2025-11-05 | — | — | EP | disclosed |
| WO-2024145623-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS AS INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |