Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21631806 | 0.86 | NOS1 (0.34) | NOS1AXLPTPN6METAP2IDO1 | |
| SCHEMBL31358029 | 0.83 | METAP2 (0.36) | NOS1METAP2 | |
| SCHEMBL30975396 | 0.81 | NOS1 (0.36) | NOS1AXLPTPN6METAP2IDO1 | |
| SCHEMBL22964672 | 0.81 | NOS1 (0.36) | NOS1AXLPTPN6METAP2IDO1 | |
| SCHEMBL15265828 | 0.78 | NOS1 (0.36) | NOS1AXLPTPN6METAP2IDO1 | |
| SCHEMBL30641268 | 0.75 | NOS1 (0.34) | NOS1AXLPTPN6METAP2IDO1 | |
| SCHEMBL20577534 | 0.75 | AXL (0.37) | NOS1AXLPTPN6METAP2 | |
| SCHEMBL29366451 | 0.74 | NOS1 (0.40) | NOS1AXLMETAP2IDO1TDO2 | |
| SCHEMBL22804796 | 0.74 | NOS1 (0.40) | NOS1AXLMETAP2IDO1TDO2 | |
| SCHEMBL22805932 | 0.72 | NOS1 (0.36) | NOS1AXLPTPN6METAP2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228489-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228489-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | CHRM1, CHRM3, CHRM2 | NOS1 2108/4885AXL 2103/4885PTPN6 1412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.