Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262741 | 0.87 | KDR (0.38) | HTR6BACE1MEN1KMT2ALMNA | |
| SCHEMBL1976235 | 0.85 | CNR2 (0.44) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1989680 | 0.85 | HTR2C (0.37) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL303078 | 0.80 | CNR2 (0.55) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1966538 | 0.78 | LMNA (0.42) | HTR6BACE1MEN1KMT2ALMNA | |
| SCHEMBL318081 | 0.78 | DRD4 (0.39) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1971605 | 0.77 | CNR2 (0.38) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL3262739 | 0.73 | POLB (0.47) | LMNAPOLBNPC1EGFRFGFR1 | |
| SCHEMBL1965541 | 0.73 | KMT2A (0.52) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL302086 | 0.73 | CNR2 (0.43) | CNR2HTR2CHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |