Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Montirelin SCHEMBL4955895 | 1.00 | TRHR (0.55) | TRHR | |
| Montirelin SCHEMBL7354006 | 1.00 | TRHR (0.55) | TRHR | |
| Montirelin SCHEMBL7311976 | 1.00 | TRHR (0.55) | TRHR | |
| Montirelin SCHEMBL29405744 | 1.00 | TRHR (0.55) | TRHR | |
| Montirelin SCHEMBL3095581 | 0.99 | TRHR (0.54) | TRHR | |
| Montirelin SCHEMBL8498903 | 0.96 | TRHR (0.52) | TRHR | |
| SCHEMBL7318759 | 0.91 | TRHR (0.54) | TRHR | |
| SCHEMBL14028667 | 0.90 | TRHR (0.43) | TRHR | |
| SCHEMBL7310894 | 0.89 | TRHR (0.52) | TRHR | |
| SCHEMBL8257280 | 0.89 | TRHR (0.42) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866711-B1 | MONTIRELIN FOR INHIBITING SLEEP APNEA | GRUENENTHAL GMBH (DE) | 2006-07-26 | — | — | EP | claimed |
| EP-0862429-A4 | METHOD OF ADJUSTING THE CIRCADIAN RHYTHM OF A MAMMAL | GRUENENTHAL GMBH (DE) | 2003-05-28 | — | — | EP | claimed |
| EP-0866711-A4 | METHOD OF INHIBITING SLEEP APNEA | GRUENENTHAL GMBH (DE) | 2003-04-16 | — | — | EP | claimed |
| US-5968932-A | ADMINISTERING 6-METHYL-5-OXO-3-THIOMORPHOLINYLCARBONYL-L-HISTIDYL-L-PROLINAM IDE | GRUENENTHAL GMBH (DE) | 1999-10-19 | — | — | US | claimed |
| US-5932541-A | 6-METHYL-5-OXO-3-THIOMORPHOLINYLCARBONYL-L-HISTIDYL-L-PROLINAM IDE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | GRUENENTHAL GMBH (DE) | 1999-08-03 | — | — | US | claimed |
| EP-0866711-A1 | METHOD OF INHIBITING SLEEP APNEA | Grünenthal GmbH (DE) | 1998-09-30 | — | — | EP | claimed |
| EP-0862429-A1 | METHOD OF ADJUSTING THE CIRCADIAN RHYTHM OF A MAMMAL | Grünenthal GmbH (DE) | 1998-09-09 | — | — | EP | claimed |
| WO-1997015309-A1 | METHOD OF INHIBITING SLEEP APNEA | GRUENENTHAL, GMBH (DE) | 1997-05-01 | — | — | WO | claimed |
| WO-1997015301-A1 | METHOD OF ADJUSTING THE CIRCADIAN RHYTHM OF A MAMMAL | GRUENENTHAL GMBH (DE) | 1997-05-01 | — | — | WO | claimed |
| EP-0185210-B1 | USE OF DIPEPTIDE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF SUFFERERS FROM AMYOTROPHIC LATERAL SCLEROSIS | Grünenthal GmbH (DE) | 1991-06-12 | — | — | EP | claimed |
| EP-0188810-B1 | USE OF DIPEPTIDE DERIVATIVES FOR THE PREVENTION OR TREATMENT OF POST-TRAUMATIC SPINAL AND/OR CEREBRAL NERVE DISORDERS | Grünenthal GmbH (DE) | 1990-10-31 | — | — | EP | claimed |
| US-4956364-A | 6-ALKYL-5-OXO-3-THIOMORPHOLINYLCARBONYLHISTIDYLPROLINAMIDE | NIPPON SHINYAKU CO., LTD. (JP) | 1990-09-11 | — | — | US | claimed |
| US-4906614-A | Method of treating posttraumatic nervous injuries with dipeptide derivatives | GRUENENTHAL GMBH (DE) | 1990-03-06 | — | — | US | claimed |
| US-4877784-A | ANTIEPILEPTIC AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-31 | — | — | US | claimed |
| US-4788179-A | Method of treating amyotrophic lateral sclerosis with dipeptide derivatives and pharmaceutical compositions for use therein | GRUENENTHAL GMBH (DE) | 1988-11-29 | — | — | US | claimed |
| EP-0188810-A2 | Use of dipeptide derivatives for the prevention or treatment of post-traumatic spinal and/or cerebral nerve disorders | Grünenthal GmbH (DE) | 1986-07-30 | — | — | EP | claimed |
| EP-0185210-A2 | Use of dipeptide derivatives for the preparation of medicaments for the treatment of sufferers from amyotrophic lateral sclerosis | Grünenthal GmbH (DE) | 1986-06-25 | — | — | EP | claimed |
| JP-63316724-A | — | — | None | — | — | JP | disclosed |
| US-4788179-A | Method of treating amyotrophic lateral sclerosis with dipeptide derivatives and pharmaceutical compositions for use therein | GRUENENTHAL GMBH (DE) | 1988-11-29 | — | — | US | disclosed |
| EP-0185210-A2 | Use of dipeptide derivatives for the preparation of medicaments for the treatment of sufferers from amyotrophic lateral sclerosis | Grünenthal GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |