Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984054 | 1.00 | PDE2A (0.42) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983795 | 0.97 | PDE2A (0.42) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983420 | 0.93 | HRH4 (0.41) | PDE2ADRD2LTA4HALDH1A1HRH4 | |
| SCHEMBL30983469 | 0.92 | PDE2A (0.40) | PDE2ADRD2KDM4EALDH1A1ALK | |
| SCHEMBL30983378 | 0.91 | HTR6 (0.41) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983531 | 0.91 | PDE2A (0.43) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983477 | 0.91 | PDE2A (0.42) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983609 | 0.90 | PDE2A (0.42) | PDE2ADRD2LTA4HKDM4EALDH1A1 | |
| SCHEMBL30983822 | 0.90 | DRD2 (0.42) | DRD2LTA4HKDM4EALDH1A1HRH4 | |
| SCHEMBL30983522 | 0.89 | PDE2A (0.41) | PDE2ADRD2LTA4HKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |