Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
| ▸ | IGF1R | P08069 | 9/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ARNT | P27540 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984008 | 0.86 | EGFR (0.39) | EGFRIGF1RPKMMAPTALDH1A1 | |
| SCHEMBL30983969 | 0.82 | ALDH1A1 (0.34) | EGFRIGF1RPKMMAPTALDH1A1 | |
| SCHEMBL30983977 | 0.82 | KCNH2 (0.35) | EGFRIGF1RPKMBACE1WDR5 | |
| SCHEMBL30984084 | 0.72 | CA1 (0.44) | EGFRL3MBTL1ALDH1A1KMT2ANPC1 | |
| SCHEMBL31269026 | 0.72 | CA1 (0.46) | EGFRIGF1RMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30983904 | 0.70 | KCNH2 (0.38) | ALDH1A1SMN1; SMN2BACE1WDR5 | |
| SCHEMBL30983870 | 0.68 | MEN1 (0.32) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30983787 | 0.67 | MEN1 (0.31) | ALDH1A1MEN1KMT2A | |
| SCHEMBL31269514 | 0.67 | CA1 (0.44) | EGFRMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL30983974 | 0.66 | KMT2A (0.31) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |