Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PDE8A | O60658 | 1/20 | 0.30 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983969 | 0.81 | ALDH1A1 (0.34) | KCNH2TLR7BACE1KDM4EALDH1A1 | |
| SCHEMBL30983977 | 0.81 | KCNH2 (0.35) | KCNH2TLR7BACE1KDM4EWDR5 | |
| SCHEMBL30984028 | 0.81 | MAOA (0.41) | KDM4EALDH1A1HPGDHTTPGK1 | |
| SCHEMBL30984085 | 0.75 | PSMB1 (0.43) | BACE1KDM4EALDH1A1HPGDKDM4C | |
| SCHEMBL30984008 | 0.73 | EGFR (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL30984066 | 0.70 | EGFR (0.38) | BACE1ALDH1A1WDR5SMN1; SMN2 | |
| SCHEMBL30983918 | 0.70 | MAPK1 (0.49) | KDM4CMAPK1RAF1HTTSMN1; SMN2 | |
| SCHEMBL30983967 | 0.66 | RECQL (0.42) | KDM4EALDH1A1HPGDMAPK1HTT | |
| SCHEMBL4307817 | 0.64 | KCNH2 (0.43) | KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL29774129 | 0.64 | L3MBTL1 (0.42) | KDM4EALDH1A1HPGDWDR5PDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |