Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | WNT3A | P56704 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984318 | 0.88 | WRN (0.45) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B | |
| SCHEMBL30984158 | 0.86 | WRN (0.53) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B | |
| SCHEMBL30984191 | 0.86 | WRN (0.49) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B | |
| SCHEMBL30984280 | 0.86 | WRN (0.49) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B | |
| SCHEMBL30984247 | 0.85 | WRN (0.49) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B | |
| SCHEMBL25036852 | 0.85 | WRN (0.61) | WRNPIK3CDPIK3CBMAPT | |
| SCHEMBL30038447 | 0.85 | WRN (0.61) | WRNPIK3CDPIK3CBMAPT | |
| SCHEMBL30984132 | 0.85 | WRN (0.35) | WRNPIK3CDPIK3CBPIK3CGTHRB | |
| SCHEMBL31713883 | 0.84 | WRN (0.49) | WRNPIK3CDPIK3CBPIK3CAMAPT | |
| SCHEMBL25037046 | 0.82 | WRN (0.58) | WRNPIK3CDPIK3CBPIK3CGPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |