Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984280 | 0.92 | WRN (0.49) | WRNPIK3CDPIK3CGPIK3C2BPIK3CB | |
| SCHEMBL30984191 | 0.92 | WRN (0.49) | WRNPIK3CDPIK3CGPIK3C2BPIK3CB | |
| SCHEMBL30984113 | 0.88 | WRN (0.47) | WRNPIK3CDPIK3CGPIK3C2BPIK3CB | |
| SCHEMBL30984167 | 0.86 | WRN (0.52) | WRNPIK3CDPIK3CGPIK3C2BPIK3CB | |
| SCHEMBL30984247 | 0.86 | WRN (0.49) | WRNPIK3CDPIK3CGPIK3C2BPIK3CB | |
| SCHEMBL31713883 | 0.83 | WRN (0.49) | WRNPIK3CDPIK3CBPIK3CAMAPT | |
| SCHEMBL25036704 | 0.83 | WRN (0.57) | WRNPIK3CDPIK3CGPIK3C2BWDR5 | |
| SCHEMBL30038198 | 0.83 | WRN (0.57) | WRNPIK3CDPIK3CGPIK3C2BWDR5 | |
| SCHEMBL25036852 | 0.83 | WRN (0.61) | WRNPIK3CDPIK3CBMAPTPOLB | |
| SCHEMBL30038447 | 0.83 | WRN (0.61) | WRNPIK3CDPIK3CBMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |