Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30037526 | 0.89 | WRN (0.58) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL25037046 | 0.89 | WRN (0.58) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984167 | 0.88 | WRN (0.52) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL31245742 | 0.87 | WRN (0.62) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984126 | 0.87 | WRN (0.55) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984113 | 0.86 | WRN (0.47) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL25035206 | 0.86 | WRN (0.59) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30038317 | 0.86 | WRN (0.59) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984220 | 0.85 | WRN (0.56) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984123 | 0.85 | WRN (0.56) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |