Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30984123 | 0.92 | WRN (0.56) | WRNPIK3CDPIK3C2BPIK3CGWDR5 | |
| SCHEMBL30984220 | 0.92 | WRN (0.56) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL25036704 | 0.89 | WRN (0.57) | WRNPIK3CDPIK3C2BPIK3CGWDR5 | |
| SCHEMBL30038198 | 0.89 | WRN (0.57) | WRNPIK3CDPIK3C2BPIK3CGWDR5 | |
| SCHEMBL31245742 | 0.89 | WRN (0.62) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984158 | 0.88 | WRN (0.53) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984310 | 0.87 | WRN (0.57) | WRNPIK3CDPIK3C2BPIK3CGPIK3CB | |
| SCHEMBL30984106 | 0.87 | WRN (0.54) | WRNPIK3CDPIK3C2BPIK3CGWDR5 | |
| SCHEMBL30984318 | 0.86 | WRN (0.45) | WRNPIK3CDPIK3C2BPIK3CGWDR5 | |
| SCHEMBL25037208 | 0.86 | WRN (0.58) | WRNPIK3CDPIK3C2BPIK3CGWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153155-A1 | DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2024-07-25 | — | — | WO | disclosed |