SCHEMBL30984741

SCHEMBL30984741

O=C1CCC(N2Cc3ccc(N4CCC5(CCC(N6CCN(c7ccc([N+](=O)[O-])cc7)CC6)CC5)CC4)cc3C2=O)C(=O)N1

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 17/20 0.48
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ IKZF2 Q9UKS7 1/20 0.44
▸ DDB1 Q16531 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30985114 0.96 CRBN (0.46) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30984672 0.94 CRBN (0.47) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30985073 0.94 IKZF2 (0.49) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30985124 0.92 IKZF2 (0.53) CRBNIKZF2DDB1
SCHEMBL30984941 0.89 CRBN (0.47) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30984919 0.89 CRBN (0.61) CRBNIKZF2DDB1
SCHEMBL30985051 0.88 CRBN (0.47) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30985042 0.88 MEN1 (0.42) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL29986754 0.86 CRBN (0.52) CRBNMEN1KMT2AIKZF2DDB1
SCHEMBL30985169 0.85 CRBN (0.58) CRBNIKZF2DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024146502-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2024-07-11 — — WO disclosed
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